Fig. 6.

Effect of CAPE at low doses on sodium arsenate-induced aggregation in U2OS-mot-GFP and cell survival in U2OS cell lines. a Schematic diagram showing the protein aggregation and recovery assay. b, c Aggregation of GFP in sodium arsenate-treated and recovered (either in control or CAPE-supplemented medium). Time-dependent response of cells to CAPE treatment is shown in c. d, e Viability of cells treated with sodium arsenate followed by recovery either in control or CAPE-supplemented medium and morphological observations (e). f Western blotting of control, sodium arsenite, and CAPE-treated cells for HSP70 and HIF-1α proteins showed induction of HIF-1α, but not of HSP70, with CAPE