Fig. 3.

Pathological features of the kidney in the different treatment groups. a−c In the Aspirin group, no obvious damage to renal tubule epithelial cells can be seen. d−f In the Aspirin + Heat group, after 5 h of heat treatment, the renal tubule epithelial cells showed acute degeneration (upwards arrow); after 24 h of heat stress, acute degeneration was still the main pathological change, but karyopyknosis (filled triangle) was also observed. g−i In the Heat group, severe damage to renal tubule epithelial cells can be observed (upwards arrow), characterized by disappearance of the nucleus and karyopyknosis (filled triangle) (H&E staining, ×400, 1 bar = 20 μm)