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Initial full factorial design of both formulations, providing the lower (−1), upper (+1) and (0) central point level for each variable.
| Variables | Levels |
||
|---|---|---|---|
| −1 | 0 | +1 | |
| Formulation 1 | |||
| Tween 80 | 0.125 | 0.25 | 0.50 |
| PVP K 30 | 0.125 | 0.25 | 0.50 |
| Formulation 2 | |||
| Tween 80 | 0.125 | 0.25 | 0.50 |
| Span 80 | 0.125 | 0.25 | 0.50 |
