Table 2.
The influence of tensile force on characteristics of obtained orally disintegrating tablets.
| Formulation | Tensile force (kN) |
Hardness (N) | Friability (%) | Disintegration time (s) |
||
|---|---|---|---|---|---|---|
| Upper punch | Lower punch | In vivo | In vitro | |||
| T1 | 1.2 | 1.0 | 21.0 ± 1.2 | 3.23 | 10 | 9 |
| T2 | 1.5 | 1.1 | 25.2 ± 1.3 | 2.41 | 11 | 9 |
| T3 | 2.0 | 1.2 | 30.3 ± 2.3 | 1.52 | 18 | 15 |
| T4 | 2.5 | 1.5 | 35.4 ± 1.5 | 1.81 | 25 | 20 |
| T5 | 3.0 | 1.7 | 40.0 ± 1.3 | 1.12 | 34 | 28 |
| T6 | 3.7 | 1.9 | 56.9 ± 2.5 | 0.59 | 30 | 31 |
| T7 | 4.2 | 2.4 | 61.0 ± 1.5 | 0.38 | 40 | 36 |
| T8 | 6.0 | 5.5 | 60.0 ± 1.5 | 0.48 | 45 | 41 |
| T9 | 6.5 | 5.7 | 75.1 ± 2.4 | 0.80 | 67 | 64 |
| T10 | 7.2 | 6.8 | 79.0 ± 4.6 | 0.92 | 78 | 60 |