Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 21;6:88. doi: 10.3389/fcell.2018.00088

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Unal Eroglu, Mulligan, Zhang, White, Sengupta, Nie, Lu, Qian, Xu, Pei, Burgess, Saxena and Mumm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Rod but not cone photoreceptors are reduced in rho^djh503+/− mutants. (A) The 1d1 antibody (magenta), which recognizes Rhodopsin, labels the outer segments of wildtype rod cells. The labeling pattern is similar in both wildtype and mutants at 3 dpf. At 6 dpf, 1d1 antibody labeling is restricted to the proliferating marginal zone in rho^djh503+/− mutants (*), but remains throughout the ONL in wildtype retinas. The white boxed region in the 6 dpf images are enlarged in the panels to the right showing that the 1d1 antibody labels YFP-expressing rod cells (green, arrows). (B) The zpr1 (magenta) antibody labeled cone cells do not show an obvious difference between wildtype and mutant retinas at 4 and 7 dpf. The boxed region in the 7 dpf images is enlarged to the right showing no overlay between zpr1 antibody staining and YFP-expressing rod cells (green). DAPI (blue) was used to stain cell nuclei. Arr3a, Arrestin 3a; DAPI, 4′,6-diamidino-2-phenylindole; dpf, days post-fertilization; ONL, outer nuclear layer; rho, rhodopsin; Rho, Rhodopsin; YFP, yellow fluorescent protein.