Table 1.
A summary of previously reported cases of disseminated peritoneal leiomyomatosis with malignant transformation in women.
| Study | Age | Obstetrical History | Clinical Presentation | OC Use | Location | MT Interval | Malignancy | Surgery | Adjuvant Therapy | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| Rubin et al. [4] | 27 | G1 | Found at cesarean section | ND | 1. Pelvis 2. Bone metastases |
6 months | Small spindle cell sarcoma | 1. TAH and RSO 2. Partial omentectomy 3. Resection of peritoneal implants |
Radiotherapy Chemotherapy: 1. Doxorubicin 2. Cyclophosphamide 3. Cisplatin |
Died 23 months |
| Akkersdijk et al. [3] | 25 | G0 | Acute right lower abdominal pain. | None | 1. Omentum 2. Colon 3. Small intestine |
1 year | LMS | 1. TAH and RSO 2. Partial omentectomy 3. Resection of peritoneal implants |
Hormonal therapy: 1. GnRH agonists |
Died 22 months |
| Abulafia et al. [6] | 20 | G0 | Left lower abdominal pain for 2 months | None | 1. Omentum 2. Pelvis |
1 year | LMS | 1. Cytoreductive surgery 2. Omentectomy |
Hormonal therapy: 1. Leuprolide acetate Chemotherapy: 1. Doxorubicine 2. Ifosfamide 3. Etoposide |
Died 24 months |
| Raspagliesi et al. [5] | 26 | G0 | ND | None | 1. Left adnexa | 4 months | LMS | 1. Adnexectomy | Chemotherapy: 1. Infliximab 2. Dacarbazine 3. Epirubicin |
No recurrences after 3 years |
| Fulcher AS et al. [7] | 48 | G2 | Dyspareunia and severe pelvic pain | None | 1. Pelvis 2. Subdiaphragmatic mass |
3 months | LMS | 1. TAH and BSO 2. Omentectomy 3. Resection of peritoneal nodules 4. Biopsy of subdiaphragmatic mass |
Chemotherapy: 1. Epirubicin 2. Ifosfamide 3. Dacarbazine |
Died |
| Morizaki et al. [9] | 33 | G0 | Lower abdominal pain | None | 1. Peritoneum 2. Mesentery 3. Descending colon 4. Pelvis |
4 months | 1. LMS 2. Fibrosarcoma |
1. Laparotomy 2. Resection of peritoneal nodules |
Chemotherapy: 1. Cisplatin 2. Cyclophosphamide |
Died 11 months |
| Sharma et al. [10] | 55 | ND | Abdominal swelling for 1 year |
None | 1. Omentum 2. Mesentery |
1 year | LMS | 1. Laparotomy 2. Resection of peritoneal nodules |
No | ND |
| Lamarca et al. [24] | 37 | G0 | Increased abdominal perimeter | None | 1. Peritoneal cavity | 0 month | LMS | 1. TAH and BSO 2. Tumor mass resection |
Hormonal therapy: 1. Triptorelin Chemotherapy: 1. Adriamicine 2. Gemcitabine 3. Isophosphamide 4. Trabectedin 5. Sorafenib |
Died 24 months |
| Zyla MM et al. [23] | 26 | G0 | Abdominal pain and vaginal bleeding | OCP | 1. Omentum 2. Peritoneal cavity 3. Pelvis 4. Retroperitoneal space |
1 year | Endometrial sarcoma |
1. TAH and BSO 2. Omentectomy 3. Appendectomy 4. Pelvic lymphadenectomy 5. Tumoral mass resection |
Hormonal therapy: 1. GnRH agonists |
No recurrences after 1 year |
| Tun AM et al. [11] | 56 | ND | Abdominal distension | ND | 1. Pelvis 2. Peritoneum 3. Omentum 4. Lung and liver metastases |
ND | LMS | 1. Exploratory laparotomy 2. Debulking of the tumors |
Chemotherapy: 1. Gemcitabine 2. Docetaxel |
Died 5 months |
| Shahin NA et al. [12] | 48 | ND | Menorrhagia for one year |
None | 1. Right lumbar 2. Pelvis 3. Left upper abdomen 4. Douglas pouch |
6 months | LMS | 1. Laparotomy 2. Resection of the mass |
Chemotherapy | Died 15 months |
| Syed M et al. [12] | 40 | ND | Abdominal pain for 7 months | OCP | 1. Peritoneum 2. Bilateral adnexa 3. Recto-uterine pouch 4. Pre-vesical space 5. Left rectus 6. Abdominis muscle |
3 years | LMS | 1. TAH and BSO 2. Debulking of the tumors |
ND | ND |
LMS: leiomyosarcoma, ND: no data, OC: oral contraceptives, TAH: transabdominal hysterectomy, RSO: Right side Salpingo-Oophorectomy, MT Interval: malignant transformation interval time.