Table 1.
In vitro antimycobacterial and cytotoxicity activities of PA and INH against M.tb strains.
| M.tb Strains | MIC (µM) | Cytotoxicity (IC50) (µM) for PA and INH | Selectivity Index (SI) | ||
|---|---|---|---|---|---|
| PA | INH | PA | INH | ||
| M.tb H37Rv CNCTC My 331-88 (ATCC 27294) | 3.2 | 5.8 | >75 | >23.4 | >13.0 |
| M.tb-01 * | 3.9 | 5.5 | >75 | >19.2 | >13.6 |
| M.tb-02 * | 3.6 | 5.6 | >75 | >20.8 | >13.4 |
| M.tb-03 * | 3.8 | 5.4 | >75 | >19.7 | >13.9 |
| M.tb-04 * | 4.1 | 5.8 | >75 | >18.3 | >13.0 |
| M.tb-05 * | 3.2 | 5.7 | >75 | >23.4 | >13.2 |
| M.tb-06 * | 3.5 | 5.7 | >75 | >21.4 | >13.2 |
| M.tb-07 * | 3.9 | 5.5 | >75 | >19.2 | >13.6 |
| M.tb-08 * | 4.0 | 5.7 | >75 | >18.6 | >13.2 |
The values represented are the average obtained from three independent experiments, each performed in triplicate. M.tb Mycobacterium tuberculosis; CNCTC: The Czech National Collection of Type Cultures obtained from National Institute of Public Health (Prague, Czech Republic); MIC: minimum inhibitory concentration; PA: psoromic acid; INH: isoniazid; IC50: half maximal inhibitory concentration; SI: selectivity index (IC50/MIC). *: Clinical isolates (Motol University Hospital in Prague, Czech Republic).