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. 2018 Aug 21;9:933. doi: 10.3389/fphar.2018.00933

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Copyright © 2018 Bögeholz, Pauls, Dechering, Frommeyer, Goldhaber, Pott, Eckardt, Müller and Schulte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct action potential kinetics in atrial versus ventricular myocytes. (A) Representative action potentials in atrial (left) and ventricular cardiomyocytes without (mid) and with (right) an EAD. Atrial myocytes exhibited a depolarized resting membrane potential (RMP) (B), a decreased maximal action potential (AP) upstroke velocity (V_max) (C), a decreased AP amplitude (D), and prolonged action potential duration to 50% decay (APD₅₀) (E). (F) Though a fraction of ventricular cells exhibited incessant EADs leading to AP prolongation (raw values within the dashed box), the average APD₉₀ was unaltered between both cell types. ^∗p < 0.05 atrial vs. ventricular; n.s., non-significant.