FIGURE 2.

Influence of geraniin on rate of wound closure. Full thickness wounds of approximately 20 mm in diameter were excised on the dorsal region of rats. The excised wounds were topically treated with geraniin (0.1, 0.2, and 0.4% w/w) formulated as aqueous cream. Wound diameter was measured on days 1, 3, 5, 7, 9, 11, and 13 post injuries. (A) Time-course curve, (B) AUC of time course curve. Excised wounds were treated with 0.1, 0.2, and 0.4% w/w geraniin. Vehicle group was treated with aqueous cream base. SSPD: 1% w/w silver sulphadiazine-treated wounds. Values are mean ± SEM, n = 5. ^∗∗∗p < 0.001; ^∗∗p < 0.01; ^∗p < 0.05 compared to untreated group (two-way ANOVA followed by Bonferroni’s post hoc test).