Figure 6.

Classifying prioritized phenotypes. The 58 prioritized phenotypes were classified to 3 key event levels: KE1 (subcellular), KE2 (cellular), or KE3 (system) based on their mapping in the GO hierarchy. Similar biological themes are coded (legend at bottom). A schematic summary of the meta-data is shown in lower right corner: direct interactions between cadmium (Cd) and 35 genes are reported in CTD's toxicogenomic core, and CTD's disease core reports that these 35 genes are also directly associated with Alzheimer disease, as well as independently annotated by external databases to 58 GO terms; simultaneously, CTD's phenotype module reports manually curated interactions between cadmium and these same 58 prioritized phenotypes; and CTD disease core also describes a connection between cadmium and Alzheimer disease, allowing the 58 prioritized phenotypes to be inferred (dotted arrow).