Table 1.
Diagnostic value of proGRP, NSE and their combination on SCLC
| Diseases | Biomarkers | Cutoff value | Sensitivity (%) | Specificity (%) | AUC |
|---|---|---|---|---|---|
| SCLC vs NSCLC | proGRP | 114.35 pg/mL | 86.5 | 99.1 | 0.939 |
| 65.7 pg/mL | 87.8 | 91.5 | ‐ | ||
| NSE | 17.34 μg/L | 86.5 | 84.2 | 0.886 | |
| proGRP + NSE | ‐ | 86.5 | 97.9 | 0.965 | |
| SCLC vs BLD | proGRP | 162.55 pg/mL | 83.8 | 98.9 | 0.939 |
| 65.7 pg/mL | 87.8 | 86.7 | ‐ | ||
| NSE | 17.35 μg/L | 86.5 | 91.3 | 0.923 | |
| proGRP + NSE | ‐ | 91.9 | 96.6 | 0.976 |
AUC, area under curve; BLD, benign lung diseases; NSCLC, non‐small‐cell lung cancer; ‐, no information; NSE, neuron‐specific enolase; proGRP, progastrin releasing peptide; SCLC, small‐cell lung cancer