Figure 1.

Treatment with the TLR9 antagonist IRS 869 reduces severity of PIA. A, DA.1F rats were prophylactically treated with the TLR9 antagonist, the control ODN or vehicle (phosphate‐buffered saline, PBS) according to the treatment scheme. B, Paw swelling was assessed throughout the experiment starting at day 10, and end‐point paw swelling was calculated for all groups at day 25. C, Weight changes were measured and calculated relative to the starting weight (day 0); end‐point weight change was calculated for all groups at day 25 after disease induction. Graphs show mean ± SEM with *P < .05 (n = 6 animals/group)