Figure 1.

Effects of captopril administration on Gata1 ^low mouse model of myelofibrosis. Wild‐type (wt) or Gata1 ^low mice were treated from 10 to 12 mo with either captopril 72 mg/kg/d or vehicle in drinking water. Mice were killed at 13 mo, and tissues were harvested. (A) Haematoxylin and eosin staining of bone marrow from the humeri of the three mouse cohorts. Magnification is 40×. (B, C) Gomori staining of the same histological sections shows reticulin deposition in vehicle‐treated Gata1 ^low mice. Under blinded conditions, a board‐certified pathologist (T.A.S.) scored bone marrow for reticulin. Captopril treatment resulted in decreased reticulin fibre score, with *P value < .05 (one‐tailed Mann‐Whitney test). (D) Haematoxylin and eosin staining of spleens from the three mouse cohorts. Magnification is 60×. (E) Gomori staining of the same histological sections shows reticulin deposition in vehicle‐treated Gata1 ^low mice. (F) Spleens from the three mouse cohorts were weighed, with *P value < .05