Table 2.
The echocardiographic and haemodynamic analysis of HSF1 TG mice and their littermates 1 wk after sham or LAD ligation
| Sham | MI | |||
|---|---|---|---|---|
| WT (n = 6) | HSF1 TG (n = 6) | WT (n = 6) | HSF1 TG (n = 6) | |
| LVAWd (mm) | 0.73 ± 0.02 | 0.72 ± 0.02 | 1.18 ± 0.05b | 1.16 ± 0.06 |
| LVIDd (mm) | 3.06 ± 0.3 | 3.03 ± 0.4 | 3.79 ± 0.5a | 3.19 ± 0.4c |
| EF (%) | 74.3 ± 5.9 | 75.8 ± 6.1 | 56.6 ± 4.1b | 67.9 ± 6.1c |
| HR (bpm) | 577.3 ± 47.3 | 571.0 ± 41.9 | 585.2 ± 49.5 | 579.5 ± 49.8 |
| LVESP (mm Hg) | 101.5 ± 8.3 | 103.8 ± 7.5 | 84.8 ± 6.5b | 95.6 ± 9.1c |
| LVEDP (mm Hg) | 1.4 ± 0.3 | 1.8 ± 0.4 | 9.1 ± 0.8b | 5.1 ± 0.4c |
| Max dp/dt (mm Hg/S) | 9959 ± 661.7 | 10011 ± 698.8 | 7002 ± 642.1a | 8797 ± 660.5c |
| Min dp/dt (mm Hg/S) | −9261 ± 790.8 | −9511 ± 540.1 | −5232 ± 577.3a | −6719 ± 541.2c |
LVAWd, left ventricular anterior wall end‐diastolic thickness; EF, ejection fraction; LVIDd, left ventricular internal end‐diastolic dimensions; HR, heart rate; LVESP, LV end‐systolic pressure; LVEDP, LV end‐diastolic pressure; max dp/dt, maximal contraction velocity; min dp/dt, maximal relaxation velocity.
a
P < .05.
b
P < .01 vs. WT sham mice.
c
P < .05 vs. WT MI mice.