Table 1.
Effects of butyrate supplementation on the NAS and ALT, AST, and TG levels in the liver and LBP levels in the serum1.
| Control | MCD | Control + SoB | MCD + SoB | |
|---|---|---|---|---|
| NAFLD activity score | 0.29 ± 0.11 | 4.18 ± 0.21*** | 0.21 ± 0.11### | 2.53 ± 0.24***### |
| Steatosis | 0.29 ± 0.11 | 2.29 ± 0.11*** | 0.21 ± 0.11### | 1.47 ± 0.19***## |
| Inflammation | 0.00 ± 0.00 | 1.12 ± 0.08*** | 0.00 ± 0.00### | 0.33 ± 0.13### |
| Ballooning | 0.00 ± 0.00 | 0.76 ± 0.18** | 0.00 ± 0.00## | 0.73 ± 0.23* |
| Alanine aminotransferase (U/L) | 19.29 ± 0.64 | 332.25 ± 26.55** | 19.69 ± 1.51## | 137.13 ± 11.33***# |
| Aspartate aminotransferase (U/L) | 91.93 ± 2.98 | 400.25 ± 25.05** | 111.31 ± 5.39*## | 240.38 ± 19.68**## |
| Triglyceride (nmol/mg protein) | 277.86 ± 32.15 | 574.89 ± 29.39*** | 326.98 ± 41.95### | 460.26 ± 35.25**# |
| Lipopolysaccharide binding protein (μmol/L) | 329.43 ± 13.13 | 398.82 ± 7.84*** | 317.81 ± 11.74### | 321.67 ± 9.31### |
1Data are presented as the means ± SEM of 15–17 mice per group. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 compared with mice fed with the control diet. #P < 0.05, ##P < 0.01, ###P < 0.001 compared with mice fed with the MCD diet.