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. 2018 Aug 21;9:1131. doi: 10.3389/fphys.2018.01131

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Copyright © 2018 Pun, Guadagni, Bettauer, Drogos, Aitken, Hartmann, Furian, Muralt, Lichtblau, Bader, Rawling, Protzner, Ulrich, Bloch, Giesbrecht and Poulin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in cognition (CANTAB outcome parameters with RM-ANOVA) over two cycles (ΔCANTAB = Cycle 2 – Cycle 1) at very high altitude during acute, subacute and repeated exposure comparing with controls. Figure has three horizontal box panels. The first panel (A–C) illustrates “processing speed” i.e., changes in Reaction Time (RTI) parameters (ΔRTIFMDRT, ΔRTIFMMT, and ΔRTIFMTSD), the second box panel contains “attention” in which first panel within the box (D–F) shows changes in Attention Switching Task (AST) parameters (ΔASTTC, ΔASTLM, and ΔASTLSD) while the second panel within the second box (G–I) shows changes in Rapid Visual Processing (RVP) parameters (ΔRVPA, ΔRVPMDL, and ΔRVPLSD) and the third box panel (J–L) shows changes in One Touch Stockings of Cambridge (OTS) parameters (ΔOTSPSFC, ΔOTSMLFC, and ΔOTSLFCSD). The x-axis depicts different time points of data collection for Altitude exposure and Control groups at Baseline (BL), Acute exposure (HA1) and Acclimatization exposure (HA6). The y-axis depicts changes in cognitive parameters as mean ± SD for Altitude and Control group. Symbols: Black filled bars, Altitude group; empty bars, Control group; Δ, Change; ms, milliseconds; n, number. BL, baseline; HA1, acute exposure to altitude (day 1); HA6, acclimatization exposure to altitude (day 6); RTI, Reaction Time; AST, Attention Switching Task; RVP, Rapid Visual Processing; OTS, One Touch Stockings of Cambridge; ΔRTIFMDRT, RTI Median Five-choice Reaction Time; ΔRTIFMMT, RTI Mean Five-choice Movement Time; ΔRTIFMTSD, RTI Five-choice Movement Time Standard Deviation; ΔASTTC, AST Total Correct; ΔASTLM, AST Latency Mean; ΔASTLSD, AST Latency Standard Deviation; ΔRVPA, Rapid Visual Processing Accuracy; ΔRVPMDL, ΔRVP Mean Response Latency; ΔRVPLSD, RVP Response Latency Standard Deviation; ΔOTSPSFC, OTS Problems Solved on First Choice; ΔOTSMLFC, OTS Mean Latency First Choice; ΔOTSLFCSD, OTS Latency to First Choice Standard Deviation.