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. 2001 Nov 13;98(24):13790–13795. doi: 10.1073/pnas.191502998

Figure 1.

Figure 1

Hierarchical clustering defines subclasses of lung tumors. Two-dimensional hierarchical clustering of 203 lung tumors and normal lung samples was performed with 3,312 transcript sequences. The normalized expression index for each transcript sequence (rows) in each sample (columns) is indicated by a color code (see EXPRESSION INDEX bar at lower left of figure). (A) Clusters of genes with high relative expression in normal lung (NL, pink branch). (B) Neuroendocrine tumors: small-cell lung cancer (SCLC, gold branch) and pulmonary carcinoids (COID, light blue branch). (C) squamous cell lung carcinomas with keratin markers (SQ, light green branch). (D) Proliferation-related markers. Adenocarcinomas resected from the lung (black branches) and a subset of adenocarcinomas suspected as colon metastases (red branch) are indicated. Color bars on the right correspond to regions displayed in Fig. 10.