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. 2018 Aug 20;7(8):225. doi: 10.3390/jcm7080225

Figure 2.

Figure 2

Structure of immunoglobulin A1 (IgA1) hinge region with O‑glycans. In the hinge region, IgA1 potentially has three to six O-glycans. The O-glycan attached to IgA1 via the link with serine/threonine residues and oxygen atoms. The structure of O-glycans consisted of N-acetylgalactosamine (GalNAc), galactose and/or sialic acid. The attachment of GalNAc to serine/threonine residues by GalNAc transferases is first step of glycosylation. Second step, the GalNAc can be added galactose by glycoprotein N-acetylgalactosamine 3-β-galactosyltransferase (C1GALT1) or sialic acid by α-N-acetylgalactosaminide α2,6-sialyltransferase 2 (ST6GALNAC2).