Table 2.

The significant enriched analysis of DEGs in osteoarthritis.

Expression	Category	Term	Description	Gene Count	P-Value
DOWN-DEGs	BP	GO:0006911	phagocytosis, engulfment	5	3.11E-05
	BP	GO:0045087	innate immune response	9	0.001731552
	BP	GO:0043406	positive regulation of MAP kinase activity	4	0.003542436
	BP	GO:0006508	proteolysis	9	0.004361459
	BP	GO:0006956	complement activation	4	0.010412249
	CC	GO:0005615	extracellular space	24	8.12E-08
	CC	GO:0005576	extracellular region	23	6.94E-06
	CC	GO:0042571	immunoglobulin complex, circulating	3	0.003820636
	CC	GO:0005886	plasma membrane	32	0.005732121
	CC	GO:0000139	Golgi membrane	9	0.008249883
	MF	GO:0004252	serine-type endopeptidase activity	7	0.001703259
	MF	GO:0008144	drug binding	4	0.006434471
	MF	GO:0034987	immunoglobulin receptor binding	3	0.007358675
	MF	GO:0008201	heparin binding	5	0.008337436
	MF	GO:0008083	growth factor activity	5	0.008701217
UP-DEGs	BP	GO:0044344	cellular response to fibroblast growth factor stimulus	7	2.20E-07
	BP	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	27	4.77E-07
	BP	GO:0051591	response to cAMP	7	3.08E-06
	BP	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	21	5.86E-06
	BP	GO:0043066	negative regulation of apoptotic process	16	1.31E-05
	CC	GO:0005634	nucleus	75	6.25E-07
	CC	GO:0005654	nucleoplasm	47	2.11E-06
	CC	GO:0005737	cytoplasm	61	0.002569078
	CC	GO:0005829	cytosol	43	0.002630227
	CC	GO:0005667	transcription factor complex	6	0.02296627
	MF	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	12	1.03E-05
	MF	GO:0005515	protein binding	106	2.10E-05
	MF	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	5	5.02E-05
	MF	GO:0044822	poly(A) RNA binding	25	7.91E-05
	MF	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	4	1.95E-04