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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Neurobiol Learn Mem. 2018 Feb 9;154:97–111. doi: 10.1016/j.nlm.2018.02.007

Figure 3. Postsynaptic metaplasticity substrates.

Figure 3

Accumulation of CP-AMPAR and NR2BR at the addicted synapse increases postsynaptic Ca2+ upon activation. The functional down-regulation and internalization of mGluR5 impairs LTD. These adaptations increase thresholds for or abolish LTD and decrease thresholds for LTP.