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. 2018 Aug 27;15:239. doi: 10.1186/s12974-018-1275-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Characterization of EVs. a The morphology of EVs from the serum of patients with ASD was evaluated using TEM (scale bar, 100 nm); the arrow points to the EV membrane. b EVs collected from the serum samples of normotypic controls (n = 3) and ASD children (n = 3) were characterized by Western blot analysis for the presence of the EV-associated proteins, CD81 and CD9. C = controls, P = patients