Table 1.
Activity of PLA2 inhibitors against promastigote, amastigote and peritoneal macrophages from BALB/c mice
| Compounds | EC50 (μΜ)a | CC50 (μM) | SIa | EC50 (μM)b | SIb |
|---|---|---|---|---|---|
| AA | 450.1 ± 45.6 | > 600 | > 1.3 | 76.9 ± 5.7 | > 7.8 |
| BEL | 15.1 ± 3.7 | > 60 | > 3.9 | 2.6 ± 0.8 | > 23.1 |
| MAFP | 50.5 ± 7.8 | > 300 | > 5.9 | 17.6 ± 7.9 | > 17.0 |
| Miltefosine | 12.6 ± 2.1 | 60.8 ± 3.1 | 4.8 | 21.6 ± 2.2 | 2.8 |
The efficacies of compounds were analyzed through effective concentration 50 (EC50), and the selective indexes (SI) were estimated
a promastigote; b amastigote