FIG. 10.

H&E staining of encapsulated islet transplants. Micrographs (200 × ) of H&E stained sections from the explanted graft showed intact hydrogel and very little or no fibrosis at the gel/tissue interface, indicated with black arrows. Tissues were explanted from rats that received encapsulated islet transplants at 40 (left), 52 (middle), and 64 (right) weeks post-transplant. The large open spaces around the explanted hydrogel material were due to changes in the gel's physical properties during paraffin embedding because of its high water content, which leaves the gel brittle and difficult to section. Scale bars = 200 μm.