Figure 3.

Effects of chronic treatment with probucol (30 mg/kg/day) on locomotion and motor balance in WT and YAC128 mice as assessed with the open field test (a and b) and the rotarod test (c and d). The distance traveled in the open field (a) and the time spent in the center of the open field (b) and the latency for the first fall (c) and the number of falls (d) in the rotarod were evaluated, and values are represented as mean ± SEM (n = 8–10 mice/group). Results were compared with repeated measures ANOVA followed by the Duncan post hoc test. ^∗ P < 0.05 when compared with the WT group and ^∗∗ P < 0.01.