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. 2018 May 9;16(2):108–119. doi: 10.1016/j.gpb.2018.03.002

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Applications of mRNA and miRNA indexes in breast cancer

Transcriptomic analyses reveal the expression patterns of both mRNAs and miRNAs. TNBC has been classified into different subtypes according to the cluster analysis of the distinct mRNA expression profiles. Additionally, high-throughput RNAi screening is widely applied to authenticate the “driver” inactivated genes and identify the hidden synthetic lethal relationships. Transcriptomic analyses also facilitate the discovery and validation of breast cancer-associated miRNAs. Therapeutic strategies, based on the inhibition and restoration of deregulated miRNAs, are now undergoing trials and hold great promise for breast cancer treatment. ASO, antisense oligonucleotide; LNA, locked nucleic acid; TuD, tough decoy.