Table 3.

Significant pairwise epistatic interactions between marker pairs for various phenotypes

Interacting marker pairs	Phenotypes controlled	F overall (>4.7)*	P	F interaction (>4.7)†	P‡
D3Mit348 × D18Mit7	Cecum hyperplasia	7.66	1.5  × 10−9	4.77	9.1  × 10−4
D8Mit94 × D18Mit124	Cecum hyperplasia	5.04	5.6  × 10−6	5.24	4.0  × 10−4
	Cecum total score	5.71	6.8  × 10−7	6.60	3.8  × 10−5
D3Mit189 × D17Mit34	anti-ECM IgG	5.49	1.3  × 10−6	6.11	8.8  × 10−5
	Percentage of IgM+ B cells	5.36	2.1  × 10−6	4.97	6.4  × 10−4

^*F statistic thresholds for significance at genome-wide level of P < 0.01. The genome-wide 0.01 threshold for the simultaneous pairwise genome scan was estimated to be 4.7 by permutation analysis. The test for interaction is based on the nominal 0.001 significance level, which coincidentally is also 4.7. 

^† Based on tabulated F distribution with 8,399 degrees of freedom. 

^‡ Based on tabulated F distribution with 4,399 degrees of freedom.