Table 4.
Provisional nomenclature for colitogenic linkages
| Locus (Chr.) | Susceptibility donor | Mode of action | Phenotype(s) controlled | Candidate genes | Potential human IBD linkage |
|---|---|---|---|---|---|
| Cdcs1 (3) | C3H | Additive:epistatic with multiple loci | Cecum/colon lesions and multiple subphenotypes | Fabpi, Egf, Nfkb1 | 4q or 1p |
| Cdcs2 (1) | C3H | Additive | Distal colon severity and hyperplasia | Casp8, Cd28, Ctla4, Icos | 2q |
| Cdcs3 (2) | C3H | Recessive | Distal colon hyperplasia, severity, ulceration, distal colon score, B cell number | Thbs1, B2m Il1, Pcna | 15q 2q |
| Cdcs4 (8) | B6 | Epistatic | Cecum hyperplasia | Defb, Defcr, Scc8 | 8p |
| Cdcs5 (17) | B6 | Recessive | Proximal colon severity, mid-colon ulceration | H2-Ea, C4/Slp, Tnf | 6p |
| Cdcs6 (18) | B6 | Epistatic | Cecum hyperplasia | Dcc, Apc, Mad2, Mad4 | 18q or 5q |