Table 1.
Properties of WT and Mutant MEK1 Alleles
| MEK1 mutants | Phosphorylation dependency | RAF dependency | |
|---|---|---|---|
| Wild type | Dependent | Dependent | |
| Class I | D67N | Dependent | Dependent |
| P124L | Dependent | Dependent | |
| P124S | Dependent | Dependent | |
| L177V | Dependent | Dependent | |
| Class II | ΔE51–Q58 | Regulated | Regulated |
| ΔF53–Q58 | Regulated | Regulated | |
| E203K | Regulated | Regulated | |
| L177M | Regulated | Regulated | |
| C121S | Regulated | Regulated | |
| F53L | Regulated | Regulated | |
| K57E | Regulated | Regulated | |
| Q56P | Regulated | Regulated | |
| K57N | Regulated | Regulated | |
| Class III | ΔL98–I103 | Independent | Independent |
| ΔI99–K104 | Independent | Independent | |
| ΔE102–I103 | Independent | Independent | |
| ΔI103–K104 | Independent | Independent | |