(A) 2D score plot of human lesional skin samples from psoriasis patients (green circles, n=5) compared with human non-lesional skin samples from psoriasis patients and skin from healthy volunteers (blue circles, n=13). 95% confidence interval is denoted by the gray ellipse. (B) 2D loading plot of lipid mediators identified in human lesional, non-lesional, and healthy skin samples. Green circles denote lesional skin patients, blue circles non-lesional and healthy control skin. (C): Ratio of SPMs vs. PG and LT in psoriasis lesional skin compared to non-lesional skin, P<0.05.