Table 1.
Zika Vaccines in Development
| Strategy | Antigen form | Candidate name | Sponsor | Clinical trial dose regimen | Phase I | Phase II | Reference |
|---|---|---|---|---|---|---|---|
| Whole inactivated virus | Formalin-Inactivated virus | ZPIV | WRAIR/BIDMC | 2-dose (days 1, 29) |
NCT02963909 NCT02952833 NCT02937233 NCT03008122 |
- | (Abbink et al., 2016) |
| PIZV/TAV-426 | TAKEDA | 2-dose (days 1, 29) | NCT03343626 | - | |||
| Zika virus vaccine (strain MR 766) | Bharat Biotech International | - | - | - | (Sumathy et al., 2017) | ||
| Subunit | DNA | GLS-5700 | GeneOne Life Science, Inc./Inovio Pharmaceuticals | 3-dose (weeks 0, 4, 12) |
NCT02809443 NCT02887482 |
- | (Tebas et al., 2017) |
| VRC-ZKADNA085-00-VP (VRC5288) | VRC/NIAID | 2~3-dose (weeks 0, 8; 0, 12; 0, 4, 8; or 0, 4, 20) | NCT02840487 | - | (Dowd et al., 2016b) | ||
| VRC-ZKADNA090-00-VP (VRC5283) | VRC/NIAID | 3-dose (weeks 0, 4, 8) | NCT02996461 | NCT03110770 | (Dowd et al., 2016b) | ||
| mRNA | mRNA-1325 | Moderna Therapeutics | - | NCT03014089 | - | (Richner et al., 2017b) | |
| mRNA-LNP | University of Pennsylvania | - | - | - | (Pardi et al., 2017) | ||
| Viral vector | MV-Zika | Themis Bioscience | 1~2-dose (day 0 or 0, 28) | NCT02996890 | - | ||
| RhAd52–prM-Env | BIDMC | - | - | - | (Abbink et al., 2016) | ||
| AdC7-M/E | BILS | - | - | - | (Xu et al., 2018) | ||
| E protein | Plant-produced ZIKV E (PzE) | Arizona State University | - | - | - | (Yang et al., 2018) | |
| E protein from S2 insect cell | University of Hawaii | - | - | - | (To et al., 2018) | ||
| Peptide | AGS-v | NIH | 2-dose (days 0 and 21) | NCT03055000 | - | ||
| VLP | Zika virus-like particles | TechnoVax, Inc | - | - | - | (Boigard et al., 2017) | |
| Live attenuated | Attenuated Zika virus | ZIKV-3′UTR-Δ10 and ZIKV-3′UTR-Δ20 | UTMB/PAHO/IEC | - | - | - | (Shan et al., 2017b) |
| Chimeric flavivirus | rDEN4Δ30 chimera | NIAID/NIH | - | - | - | ||
| JEV SA14-14-2-chimera (ChinZIKV) | BIME | - | - | - | (Li et al., 2018) | ||
| YFV 17D chimera | Sanofi | - | - | - |
Notes: WRAIR, Walter Reed Army Institute of Research; BIDMC, Beth Israel Deaconess Medical Center; NIAID, National Institutes of Allergy and Infectious Diseases; VRC, Vaccine Research Center; NIH, National Institutes of Health; UTMB, University of Texas Medical Branch; PAHO, Pan American Health Organization; IEC, Evandro Chagas Institute, Brazil; BILS, Beijing Institutes of Life Science, Chinese Academy of Sciences; BIME, Beijing Institute of Microbiology and Epidemiology; symbols “-”, data unavailable.