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. Author manuscript; available in PMC: 2019 Apr 11.
Published in final edited form as: Neuroreport. 2018 Apr 11;29(6):447–452. doi: 10.1097/WNR.0000000000000993

Figure 3. Tolerance to Δ9-THC in the formalin test.

Figure 3

Effects of once daily repeated injections of 6 mg/kg Δ9-THC (n=4–5 per time point) in the acute (Phase I; A–B) and inflammatory (Phase II; C–D) phase of the formalin test in male (A,C) and female (B,D) mice compared to vehicle (VEH) (n=9–15) in wild-type (WT) (lined bars) and S426A/S430A mutant (open bars) mice. Bars represent mean +/− SEM. Asterisk(s) indicate significant differences from vehicle; * p<0.05, **p< 0.01, ***p<0.001, ****p<0.0001.