Table 1. Demographic characteristics.

Characteristic	Category	Low LDL-C cohort	Normal LDL-C cohort
Discovery (phase 1)
N		2,982	23,771
Sex	Female	1,613 (54.1%)	13,739 (57.8%)
	Male	1,367 (45.8%)	10,007 (42.1%)
Race	European ancestry	1,830 (61.4%)	16,628 (70.0%)
	African ancestry	623 (20.9%)	3,089 (13.0%)
	Other*	556 (18.6%)	4,054 (17.1%)
Age (years)		33.2 (19.5–51.8) (N = 2,940)	42.8 (30.1–55.4) (N = 23,377)
BMI (kg/m2)		24.5 (21.0–30.3) (N = 2,508)	27.1 (23.4–32.0) (N = 19,871)
Lipid panel	LDL-C (mg/dl)	52.0 (44.0–57.0)	109.0 (100.0–119.0)
	Triglycerides (mg/dl)	88.0 (58.0–151.0) (N = 2,949)	101.0 (72.0–148.0) (N = 23,575)
	HDL-C (mg/dl)	51.0 (38.5–66.0) (N = 2,942)	51.0 (41.0–63.0) (N = 23,597)
Length of EHR (years)		6.5 (2.3–11.6) (N = 2,940)	6.9 (2.5–11.9) (N = 23,376)
Validation (phase 2)
N		5,961	47,572
Sex	Female	3,253 (54.6%)	27,392 (57.6%)
	Male	2,698 (45.3%)	20,140 (42.3%)
Race	European ancestry	3,744 (62.8%)	33,333 (70.1%)
	African ancestry	1,208 (20.3%)	6,226 (13.1%)
	Other*	1,009 (16.9%)	8,013 (16.8%)
Age (years)		33.2 (19.0–51.3) (N = 5,864)	42.6 (30.0–55.4) (N = 46,726)
BMI (kg/m2)		24.5 (20.9–30.0) (N = 5,032)	27.1 (23.4–32.1) (N = 20,128)
Lipid panel	LDL-C (mg/dl)	52.0 (44.0–57.0)	109.0 (100.0–119.0)
	Triglycerides (mg/dl)	88.0 (57.0–148.0) (N = 5,868)	102.0 (72.0–149.0) (N = 23,828)
	HDL-C (mg/dl)	51.0 (39.0–66.0) (N = 5,857)	51.0 (41.0–63.0) (N = 23,845)
Length of EHR (years)		6.6 (2.3–12.0) (N = 5,863)	6.9 (2.6–11.9) (N = 46,726)

Data are N (percent) or median (interquartile range). LDL-C and HDL-C: 1 mg/dl = 0.0256 mmol/l; triglycerides: 1 mg/dl = 0.0113 mmol/l.

*The category “Other” includes Asians, Pacific Islanders, and Native Americans as well as individuals whose race was not known.

HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.