Table 1. Demographic characteristics.
Characteristic | Category | Low LDL-C cohort | Normal LDL-C cohort |
---|---|---|---|
Discovery (phase 1) | |||
N | 2,982 | 23,771 | |
Sex | Female | 1,613 (54.1%) | 13,739 (57.8%) |
Male | 1,367 (45.8%) | 10,007 (42.1%) | |
Race | European ancestry | 1,830 (61.4%) | 16,628 (70.0%) |
African ancestry | 623 (20.9%) | 3,089 (13.0%) | |
Other* | 556 (18.6%) | 4,054 (17.1%) | |
Age (years) | 33.2 (19.5–51.8) (N = 2,940) | 42.8 (30.1–55.4) (N = 23,377) | |
BMI (kg/m2) | 24.5 (21.0–30.3) (N = 2,508) | 27.1 (23.4–32.0) (N = 19,871) | |
Lipid panel | LDL-C (mg/dl) | 52.0 (44.0–57.0) | 109.0 (100.0–119.0) |
Triglycerides (mg/dl) | 88.0 (58.0–151.0) (N = 2,949) | 101.0 (72.0–148.0) (N = 23,575) | |
HDL-C (mg/dl) | 51.0 (38.5–66.0) (N = 2,942) | 51.0 (41.0–63.0) (N = 23,597) | |
Length of EHR (years) | 6.5 (2.3–11.6) (N = 2,940) | 6.9 (2.5–11.9) (N = 23,376) | |
Validation (phase 2) | |||
N | 5,961 | 47,572 | |
Sex | Female | 3,253 (54.6%) | 27,392 (57.6%) |
Male | 2,698 (45.3%) | 20,140 (42.3%) | |
Race | European ancestry | 3,744 (62.8%) | 33,333 (70.1%) |
African ancestry | 1,208 (20.3%) | 6,226 (13.1%) | |
Other* | 1,009 (16.9%) | 8,013 (16.8%) | |
Age (years) | 33.2 (19.0–51.3) (N = 5,864) | 42.6 (30.0–55.4) (N = 46,726) | |
BMI (kg/m2) | 24.5 (20.9–30.0) (N = 5,032) | 27.1 (23.4–32.1) (N = 20,128) | |
Lipid panel | LDL-C (mg/dl) | 52.0 (44.0–57.0) | 109.0 (100.0–119.0) |
Triglycerides (mg/dl) | 88.0 (57.0–148.0) (N = 5,868) | 102.0 (72.0–149.0) (N = 23,828) | |
HDL-C (mg/dl) | 51.0 (39.0–66.0) (N = 5,857) | 51.0 (41.0–63.0) (N = 23,845) | |
Length of EHR (years) | 6.6 (2.3–12.0) (N = 5,863) | 6.9 (2.6–11.9) (N = 46,726) |
Data are N (percent) or median (interquartile range). LDL-C and HDL-C: 1 mg/dl = 0.0256 mmol/l; triglycerides: 1 mg/dl = 0.0113 mmol/l.
*The category “Other” includes Asians, Pacific Islanders, and Native Americans as well as individuals whose race was not known.
HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.