Fig 7. T cells need IFNγ to efficiently control infection in the lungs and CD8 T cells alone can only clear infection to some degree.

(A) 2x10⁷ T cells, isolated from wild-type, Ifng^-/-, Ifngr1^-/- or Prf1^-/- donors, or 1x10⁷ CD4 T cells and/or 0.8x10⁷ CD8 T cells of wild-type donors were adoptively transferred into Rag2^-/- recipients that were simultaneously infected with 10⁶ PFU MCMV-3D. Organs were analyzed at 8 dpi. (B) Quantification of the number of infected cells per lung slice. For comparison data from infected Rag2^-/- mice without T cell transfer are depicted in open circles (same data set as shown in Fig 3). Dots represent animal (mean of 4 lung slices per animal); median + interquartile range (grey); Mann-Whitney test compared to Rag2^-/- T cells without T cell transfer; Data from 2–4 independent experiments.