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. 2018 Aug 3;115(34):E8086–E8095. doi: 10.1073/pnas.1805596115

Fig. 10.

Fig. 10.

Model of hyperpolarization-dependent activation for HCN channels. Hyperpolarization causes movement of the VSD (blue) which relieves autoinhibition of the PD (orange). The binding of cyclic nucleotide (red) to the CNBD (green) removes autoinhibition of the PD.