Table 4.

Related reports in published studies which are consistent with our experimental results about the induction effect of drugs on ABC transporter

Drug	Protein	Cell line	Method	Induction effect
ADM	P-gp, MRP1, BCRP	MCF-7	RT-PCR	Louisa et al7 proved that after pretreatment with doxorubicin, the expression of P-gp, MRP1, and BCRP in MCF-7 increased significantly.
	P-gp and MRP1	HepG-2	Western blot	Ye et al14 incubated HepG-2 for 24 hours with ADM and found that the expression of P-gp and MRP1 was significantly increased.
	P-gp	SMMC-7721	Flow cytometry	Yan et al15 measured protein expression level with flow cytometry and pointed out that in SMMC-7721/ADM, P-gp expression increased.
MX	P-gp and MRP1	MCF-7	Western blot	Morrow et al9 found that P-gp and MRP1 were both increased in MCF-7/MX.
	BCRP	MCF-7	Western blot	Greijer et al13 induced MCF-7 with MX and WB results showed that the expression of BCRP increased.
	BCRP	HepG-2	RT-PCR, Western blot, flow cytometry	Ren et al12 measured high BCRP expression in HepG-2/MX.
	P-gp	PBMCs	RT-PCR, flow cytometry	Yao et al17 proved that the expression of P-gp in the resistant cells was higher.
MTX	MRP1	MCF-7	Western blot	Volk et al16 showed that MRP1 expression increased when MCF-7 was induced by MTX.
	BCRP	HL-60	Flow cytometry	Hilovska et al11 proved that BCRP was overexpressed in resistant cells.

Abbreviations: P-gp, permeability glycoprotein; MRP1, multidrug resistance-related protein 1; BCRP, breast cancer resistance proteins; ADM, adriamycin; MX, mitoxantrone; MTX, methotrexate; PBMCs, peripheral blood mononuclear cells; RT-PCR, real-time polymerase chain reaction; WB, Western blot.