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. 2018 Aug 23;11:5111–5119. doi: 10.2147/OTT.S153888

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© 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited

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miR-16 inhibited oral squamous carcinoma cell proliferation via downregulation of Wnt/β-catenin signaling pathway. (A) The Cal-27 cells were transferred with miR-16, inhibitor, or treated with Wnt signaling pathway inhibitor XAV-939, or treated with miR-16 plus R-spondin1 for 1, 2, 3, and 4 days. Cell viability was measured by MTT assay. (B) The protein levels of β-catenin, APC, and Axin-1 were measured by (C) semi-quantification of the results of Western blotting. Data presented as mean ± SD, n=3.