Table 4.
Cutoff, sensitivity, specificity, and Youden index values for the ESSENCE-Q parent-completed, telephone interview, and direct interview forms
| Cutoff value | Parent-completed form
|
Telephone interview form
|
Direct interview form
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Sensitivity (95% CI) | Specificity (95% CI) | Youden index (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Youden index (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Youden index (95% CI) | |
| ≥2 | 0.98 (0.89–0.99) |
0.78 (0.68–0.86) |
0.76 (0.57–0.85) |
0.93 (0.86–0.98) |
0.67 (0.57–0.76) |
0.60 (0.43–0.74) |
0.94 (0.85–0.98) |
0.46 (0.32–0.61) |
0.40 (0.17–0.59) |
| ≥3 | 0.96 (0.86–0.99) |
0.84 (0.75–0.91) |
0.80 (0.61–0.90) |
0.87 (0.80–0.94) |
0.73 (63.2–81.4) |
0.62 (0.43–0.75) |
0.92 (0.83–0.98) |
0.65 (0.51–0.78) |
0.57 (0.27–0.76) |
| ≥4 | 0.88 (0.75–0.95) |
0.92 (0.85–0.96) |
0.80 (0.59–0.90) |
0.84 (0.75–0.91) |
0.82 (0.73–0.89) |
0.66 (0.48–0.80) |
0.89 (0.79–0.95) |
0.81 (0.67–0.90) |
0.70 (0.46–0.85) |
| ≥5 | 0.83 (0.69–0.93) |
0.94 (0.87–0.98) |
0.77 (0.57–0.90) |
0.82 (0.72–0.89) |
0.89 (0.81–0.94) |
0.71 (0.53–0.84) |
0.86 (0.75–0.93) |
0.88 (0.77–0.96) |
0.74 (0.52–0.85) |
| ≥6 | 0.77 (0.63–0.89) |
0.95 (0.87–0.98) |
0.72 (0.50–0.87) |
0.78 (0.68–0.87) |
0.90 (0.82–0.95) |
0.68 (0.50–0.82) |
0.78 (0.66–0.88) |
0.90 (0.79–0.97) |
0.68 (0.45–0.85) |
Abbreviations: CI, confidence interval; ESSENCE-Q, Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations – Questionnaire.