Table 2. Concentration of metabolites about glycolysis in USC cells.
Compound name | Concentration (pmol/106 cells) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
USPC-1(Control) | USPC-1(Paclitaxel) | PTX-1(Control) | PTX-1(Paclitaxel) | USPC-1(Paclitaxel) vs USPC-1(Control) | PTX-1(Paclitaxel) vs PTX-1(Control) | PTX-1(Control) vs USPC-1(Control) | PTX-1(Paclitaxel) vs USPC-1(Paclitaxel) | |||||||||
Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | Ratio | P value | Ratio | P value | Ratio | P value | Ratio | P value | |
NAD+ | 3,308 | 1,684 | 5,126 | 463 | 4,368 | 509 | 4,322 | 81 | 1.5 | 0.197 | 1.0 | 0.890 | 1.3 | 0.392 | 0.8 | 0.091 |
NADH | 162 | 15 | 241 | 19 | 169 | 14 | 184 | N.A. | 1.5 | 0.006* | 1.1 | N.A. | 1.0 | 0.598 | 0.8 | N.A. |
UDP-glucose | 235 | 39 | 244 | 21 | 446 | 58 | 420 | 38 | 1.0 | 0.756 | 0.9 | 0.560 | 1.9 | 0.009* | 1.7 | 0.005* |
G6P | 56 | 20 | 58 | 12 | 126 | 13 | 94 | 5.8 | 1.0 | 0.898 | 0.7 | 0.037* | 2.3 | 0.001* | 1.6 | 0.019* |
F1, 6P | 24 | 6.4 | 40 | 6.9 | 70 | 11 | 70 | 14 | 1.7 | 0.036* | 1.0 | 0.980 | 3.0 | 0.006* | 1.7 | 0.050 |
ADP | 716 | 159 | 1,319 | 98 | 1,118 | 125 | 1,364 | 89 | 1.8 | 0.009* | 1.2 | 0.056 | 1.6 | 0.029* | 1.0 | 0.588 |
GTP | 1,815 | 707 | 2,550 | 90 | 2,059 | 280 | 1,998 | 28 | 1.4 | 0.212 | 1.0 | 0.740 | 1.1 | 0.622 | 0.8 | 0.005* |
ATP | 11,072 | 5,718 | 15,846 | 651 | 10,294 | 1,417 | 9,452 | 631 | 1.4 | 0.284 | 0.9 | 0.422 | 0.9 | 0.838 | 0.6 | 2.6E-04* |
NADPH/NADP+ | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. | N.A. |
NADH/NAD+ | 0.06 | 0.04 | 0.05 | 0.008* | 0.04 | 0.005 | 0.04 | N.A. | 0.8 | 0.591 | 1.1 | N.A. | 0.6 | 0.426 | 0.9 | N.A. |
G6P/R5P | 17 | N.A. | 89 | N.A | 15 | 2.9 | 29 | 15 | 5.1 | N.A. | 2.0 | 0.236 | 0.9 | N.A. | 0.3 | N.A. |
NAD; nicotinamide adenine dinucleotide, NADH; reduced nicotinamide adenine dinucleotide, G6P; glucose 6-phosphate, F1, 6P; fluctose 1,6-diphosphate, R5P; ribose 5-phosphate, NADPH; reduced nicotinamide adenine dinucleotide phosphate, NADP; nicotinamide adenine dinucleotide phosphate, S.D.; standard deviation, *P < 0.05, N.A.; not available.