Figure 2.
Association of 8 foreign body reaction categories and the onset of granuloma in the granuloma group. The onset of granuloma symptom can be divided into 3 Categories 1, 0 to 9 years; 2, 10 to 19 years; 3, >19 years. cCurve estimation quadratic and cubic test; *p ≤ .05; R2: Coefficient of determination for histopathology examination and the 8 foreign body reaction categories. Foreign body reactions due to injected silicone show inflammatory response followed by fibrosis. The inflammatory response peaks at 10 to 19 years, followed by decreasing activity until 25 years. Decreasing inflammatory activity was followed by increasing fibrotic activity to initiate tissue repair.