Table 4.

Changes in HDL-associated proteins over time by (A) disease activity and (B) treatment in multivariate repeated measures analyses.

A
Protein	Disease activity measure model	Disease activity estimate	p-value
Apolipoprotein AI	DAS28	−0.047	0.19
Apolipoprotein M	DAS28	0.049	0.058
	HAQ-DI	0.07	0.11
	68 Tender	0.0038	0.058
	28 Tender	0.0093	0.03
	28 Swollen	0.0076	0.178
Apolipoprotein E	HAQ-DI	0.088	0.09
Alpha1-antichymotrypsin	DAS28	0.34	0.14
	28 Tender	0.037	0.13
	HAQ-DI	0.21	0.12
Beta 2 glycoprotein 1	66 swollen	0.02	0.08
Cathelicidin antimicrobial peptide	DAS28	0.19	0.065
Clusterin	28 Tender	0.01	0.10
	28 Swollen	0.01	0.08
Fibronectin	28 Tender	0.07	0.018
	68 Tender	0.034	0.009
Fibrinogen alpha chain	28 Tender	0.02	0.068
	68 Tender	0.009	0.11
Fibulin	HAQ-DI	0.14	0.12
Ig gamma-1 chain C region	DAS28	−0.0679	0.02
Ig gamma-2 chain C region	DAS28	0.136	0.08
	68 Tender	0.0095	0.11
Ig gamma-4 chain C region	DAS28	0.22	0.11
	28 Swollen	0.06	0.045
	28 Tender	0.029	0.19
	68 Tender	0.016	0.13
Immunoglobulin J Chain	DAS28	0.085	0.16
Kininogen	68 Tender	0.0157	0.043
	66 Swollen	0.02	0.0481
Prenylcysteine oxidase 1	DAS28	0.24	0.03
	28 Tender	0.05	0.007
	68 Tender	0.02	0.01
Serum Amyloid A-1	DAS28	0.36	0.07
	HAQ-DI	0.55	0.07
Serum Amyloid A-4	DAS28	0.07	0.09
Transthyretin	28 Swollen	−0.031	0.078
	66 Swollen	−0.016	0.06
Vitronectin	28 Swollen	−0.021	0.11
	66 Swollen	−0.011	0.08

B
Protein	Disease activity measure model	Treatment estimate (Adalimumab versus Abatacept	p-value
Apolipoprotein AI	DAS28	0.14	0.37
	28 Tender	0.14	0.39
	28 Swollen	0.14	0.36
	68 Tender	0.14	0.39
	66 Swollen	0.15	0.36
	HAQ-DI	0.15	0.34
	CRP	0.14	0.37
CD5 Antigen like	DAS28	0.33	0.054
	28 Tender	0.33	0.059
	28 Swollen	0.34	0.053
	68 Tender	0.33	0.055
	66 Swollen	0.33	0.054
	HAQ-DI	0.17	0.064
	CRP	0.34	0.049
Immunoglobulin J chain	DAS28	0.57	0.009
	28 Tender	0.57	0.01
	28 Swollen	0.58	0.009
	68 Tender	0.58	0.009
	66 Swollen	0.57	0.008
	HAQ-DI	0.56	0.01
	CRP	0.59	0.008
Serotransferrin	DAS28	0.43	0.02
	28 Tender	0.43	0.02
	28 Swollen	0.42	0.02
	68 Tender	0.43	0.02
	66 Swollen	0.43	0.02
	HAQ-DI	0.47	0.01
	CRP	0.40	0.03
Serum amyloid A-1	DAS28	−1.16	0.02
	28 Tender	−1.21	0.02
	28 Swollen	−1.15	0.02
	68 Tender	−1.13	0.03
	66 Swollen	−1.17	0.02
	HAQ-DI	−1.24	0.02
	CRP	−0.86	0.06

DAS28= disease activity scale using a 28 joint count; HAQ-DI- Health assessment questionnaire disability index. Data not shown for sex, age, and treatment variables.

DAS28= disease activity scale using a 28 joint count; HAQ-DI-Health assessment questionnaire disability index. CRP= C-reactive protein. Data not shown for sex, age, and disease activity variables.