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. Author manuscript; available in PMC: 2019 Aug 10.
Published in final edited form as: Environ Mol Mutagen. 2018 Aug 10;59(7):576–585. doi: 10.1002/em.22202

Figure 2.

Figure 2

Panel A: Comparison of statistically significant ions with HMDB putative identifications, at basal levels and following IR at D1, from combination of results with the statistical tests Mann-Whitney U test and Barnard’s. Atm−/−, with the gene and protein defined as master regulators in signaling and metabolism, showed high basal metabolic differences from WT. Exposure to IR and removal of the basal levels of differential metabolites still resulted in a significant number of perturbed metabolites. Panel B: Identification of select metabolites and depiction in metabolic pathways is consistent with overall metabolic perturbations in Atm−/− compared to WT. Arrows are consistent with data presented in Table 2, representing an increase in fold change in Atm−/− of at least 1.15.