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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Drug Deliv Transl Res. 2018 Oct;8(5):1289–1299. doi: 10.1007/s13346-018-0556-y

Fig. 1. Synergistic effects of combination treatment with epigenetic drugs.

Fig. 1

Synergistic effects on MCF-7/ADR cells of the DNA methyltransferase inhibitor DAC and the histone deacetylase inhibitor SAHA, both in solution (left) vs. loaded in NGs (right). The antiproliferative effects of SAHA and DAC were assessed as a) solution or b) loaded in NGs on cells treated sequentially or simultaneously, here after 5 days. Sequential or simultaneous treatment showed no significant differences in efficacy. Combination treatment showed greater efficacy than treatment with either drug alone. Data are expressed as mean ± s.e.m., n = 6.