. Author manuscript; available in PMC: 2019 Oct 1.

Published in final edited form as: Drug Deliv Transl Res. 2018 Oct;8(5):1289–1299. doi: 10.1007/s13346-018-0556-y

Table 2.

Comparison of IC50 and combination index values of drugs post treatment in drug-resistant breast cancer cells

Drug (alone or in combination)	Mode of delivery	IC₅₀ (ng/mL)		Combination index values
Drug (alone or in combination)	Mode of delivery	5 days	10 days	5 days	10 days
DAC alone	Soln.	105 ± 4^*	923 ± 114	–	–
	NG	4312 ± 606	10 ± 0.8^*	–	–
SAHA alone	Soln.	738 ± 45	4038 ± 67	–	–
	NG	543 ± 76	379 ± 4.9^*	–	–
SAHA + DAC	Soln.	32 ± 1.4	887 ± 135	0.24 ± 0.02	0.77 ± 0.09
	NG	11 ± 0.3^*	3 ± 0.3^*	0.19 ± 0.004	0.21 ± 0.03^*

Data expressed as mean ± s.e.m; n = 6.

p < 0.05 for drug solution vs. drug in nanogels.