. Author manuscript; available in PMC: 2019 Jul 1.

Published in final edited form as: Stat Methods Med Res. 2018 Jul 12;28(9):2710–2723. doi: 10.1177/0962280218786302

Table 2.

Simulation studies for estimating the slope of rSO₂ series at pre- and post transfusion based on the naïve slope estimate and the proposed slope estimate.

		The proposed slope method	The naïve slope method
	True values	BIAS (SE)	BIAS (SE)
Simulation Case 1
Pre-trans. Slope rSO₂	0	−0.08 (6.03)	−0.82 (8.7)
Post-trans. Slope rSO₂	0	0.24 (6.74)	−1.14 (10.22)
Difference (post–pre)	0	0.16 (9.45)	−0.32 (12.52)
Simulation Case 2
Pre-trans. Slope rSO₂	0	−0.55 (6.51)	−1.48 (9.54)
Post-trans. Slope rSO₂	5	−0.66 (5.26)	−4.88 (8.69)
Difference (post–pre)	5	−0.12 (8.49)	−3.39 (12.82)
Simulation Case 3
Pre-trans. Slope rSO₂	−5	0.38 (5.62)	2.71 (9.80)
Post-trans. Slope rSO₂	5	−0.51 (6.49)	−1.64 (9.07)
Difference (post–pre)	10	−0.90 (8.61)	−4.35 (14.04)

Note: The slope values, bias and SE are on the scale of 10⁻³.