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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Curr Med Chem. 2019;26(16):2918–2932. doi: 10.2174/0929867325666180228165527

Figure 5. Potential G4 formation during mtDNA replication, transcription and translation.

Figure 5

G4 structures can form in single-stranded nucleic acids. (A) During mtDNA replication, the displaced G-rich heavy strand is a potential hotspot for the G4 formation, which would arrest the mitochondrial replication machinery (green) during second strand synthesis. (B) A model of transcription inhibition by G4 structures. The unresolved G4 structures would occur in the mtDNA template strand preventing the polymerase (blue) activity. (C) A model of translation inhibition by G4 structures forming in the mRNA.