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. 2018 Aug 28;6(16):e13824. doi: 10.14814/phy2.13824

Figure 1.

Figure 1

Chronic administration of compound 21 improves glucose tolerance and insulin sensitivity. (A) GTT. (B) calculated area under the curve from the GTT in control and C21‐treated mice. (C) insulin tolerance test (ITT). (D) calculated area under the curve from the ITT in control and C21‐treated mice. Mice were fasted for 6 h prior to basal glucose monitoring (as described in Materials and Methods) and subsequently injected i.p. with a 20% glucose solution (w/v). Blood was reanalyzed at 15, 30, 45, 60, and 120 min postinjection (C21, n = 12 per group; control, n = 10 per group. Data are represented as mean ± SEM. and analyzed by one‐way ANOVA followed by Tukey′s multiple comparison t tests where *P < 0.05 vs. control mice. GTT, glucose tolerance test.