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. 2018 Feb 2;25(8):1503–1516. doi: 10.1038/s41418-018-0058-y

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© ADMC Associazione Differenziamento e Morte Cellulare 2018

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Fig. 7 — Proposed model of RGMa regulation of TGFβ1/Smad2/3 signaling in astrocytes. By binding to a complex of its cell surface type II receptor (RII) and type I receptor activin-like kinase 5 (ALK5), TGFβ1 activate ALK5, leading to RGMa expression. RGMa forms a complex with ALK5 and Smad2/3 to facilitate ALK5-Smad2/3 interaction, promoting phosphorylation of Smad2/3. By regulating TGFβ1/Smad2/3 pathway, RGMa mediates astrocyte reactive astrogliosis and glial scar formation