Table 1.

List of twenty-seven significantly changed, and trending, ECM proteins between normal breast and IDC-s samples with aligned collagen.

IDC Proteins Changed from Normal
Protein Name	Gene Symbol	IDC/Normal  (Avg Fold Δ)	Combined p-value
Laminin β2	LAMB2	0.11‡	0.03
Mimecan/Osteoglycin	OGN	0.36	0.03
Fibromodulin	FMOD	1.6	0.10
Biglycan	BGN	2.6	0.06
Fibulin-4	EFEMP2	3.5	0.02
TGF-β Induced	TGFBI	3.8	0.06
Aggrecan	ACAN	4.0	0.03
Fibulin-3	EFEMP1	5.0	0.02
SPARC	SPARC	5.5	0.01
EMILIN-1	EMILIN1	6.1	0.01
Lysyl Oxidase-like 1	LOXL1	7.8	0.03
Latent TGF-β Binding Protein 2	LTBP2	8.1	0.01
Periostin	POSTN	15.5	0.02
Latent TGF-β Binding Protein 1	LTBP1	28.1	0.009
Fibronectin	FN1	35.8	0.02
Collagen (α1) XII	COL12A1	39.4	0.01
Tenascin-C	TNC	64.1	0.01
Transglutaminase II	TGM2	6.9‡	0.03
Fibulin-1	FBLN1	8.5‡	0.01
Versican	VCAN	12.3‡	0.01
Vitronectin	VTN	15.2‡	0.01
Thrombospondin-1	THBS1	68.7‡	0.01
Aggrin	AGRN	†	0.04
Fibrillin-2	FBN2	†	0.005
Lysyl Oxidase	LOX	†	0.04
Fibulin-2	FBLN2	**	0.005
Thrombospondin-2	THBS2	**	0.005

Twenty-seven significantly changed ECM proteins between normal breast and IDC tissues. The upper two rows indicate the consistently down-regulated proteins in IDC compared to the normal tissues. The other rows indicate consistently up-related proteins in IDC compared to the normal tissues. ^‡Protein recovered in both proteomic experiments (infinite relative fold change due to non-detectable recovery in normal tissue of one of the experiments). ^†Protein recovered only in the targeted proteomic analysis (infinite relative fold change due to non-detectable recover in normal tissue. **Protein recovered in both proteomic experiments (infinite relative fold change due to non-detectable recovery in normal tissue samples for both experiments).