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. 2018 Aug 28;8:12961. doi: 10.1038/s41598-018-31005-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of fucose synthesis blockade on in vitro infection of MA-104 cells. (a) 2F-fucose treatment efficacy was controlled by testing expression of various HBGAs (H type 2, A, B, Lewis a, Lewis b, Lewis x and Lewis y antigens) by flow cytometry: negative controls with secondary antibodies only (light grey); positive controls on DMSO treated cells (solid line); 2F-fucose treated cells (dotted line). The results provided are representative of those obtained from at least three independent experiments. (b) Infection of MA-104 cells, either DMSO (control) or 2F-fucose treated, by indicated cell culture-adapted strains of RV was quantified by fluorescence microscopy with an ArrayScan HCS Reader (Thermo Scientific). The results of each independent experiment are shown by linked control (DMSO) and treated (2F-fucose) values (n = 11 for each strain of RV).