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. 2018 Aug 28;8:12991. doi: 10.1038/s41598-018-31285-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Development of latent HA model; (B) Dose optimization of different LRA agents; (C) Effects of latency reversing agents on provirus quiescence in HA populations (14 dpi), latent HIV cells were treated with optimized dose of (a) Bryostatin: 1 nm; (b) Vorinostat: 1 µM; (c) Romidepsin: 10 nm; (d) Disulphiram: 5 µM; (e) PMA: 5 nm (positive control) (i) single agent treatment (ii) combination treatment and analyzed for HIV-1 expression for 48 hrs in comparison to untreated controls. Results demonstrate differential effects of LRAs on latent HIV-1 in HA populations. Data are from one infection experiment for each latent cell population, with columns indicating mean values for each time point. Standard errors are shown for the mean of triplicate samples.